|
Symbol Name ID |
Il21r
interleukin 21 receptor MGI:1890475 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Decreased circulating antibody level |
Panhypogammaglobulinemia |
Lymphopenia |
Leukopenia |
Autoimmune thrombocytopenia |
Recurrent sinusitis |
Recurrent pharyngitis |
Pericarditis |
Lymphadenopathy |
Mediastinal lymphadenopathy |
Splenomegaly |
Recurrent infection of the gastrointestinal tract |
Chronic hepatitis due to cryptosporidium infection |
Cholangitis |
Otitis media |
Chronic otitis media |
Recurrent otitis media |
Iridocyclitis |
Epididymitis |
Lupus nephritis |
Nephritis |
Abnormality of the immune system |
Erythema nodosum |
Discoid lupus rash |
Malar rash |
Pneumonia |
Recurrent pneumonia |
Serositis |
Decreased circulating complement C3 concentration |
Decreased circulating complement C4 concentration |
Antineutrophil antibody positivity |
Perinuclear antineutrophil antibody positivity |
Antinuclear antibody positivity |
Anti-dsDNA antibody positivity |
Anti-La/SS-B antibody positivity |
Anti-Sm antibody positivity |
Anti-U1 ribonucleoprotein antibody positivity |
Antiphospholipid antibody positivity |
Systemic lupus erythematosus |
Immunodeficiency |
Pneumocystis jirovecii pneumonia |
Recurrent infections |
Recurrent respiratory infections |
Recurrent bronchitis |
Meningitis |
| Disease(s) Associated with IL21R | |||||||||||||||||||||||||||||||||||||||||||||
| Behcet's disease | |||||||||||||||||||||||||||||||||||||||||||||
| common variable immunodeficiency | |||||||||||||||||||||||||||||||||||||||||||||
| immunodeficiency 56 | |||||||||||||||||||||||||||||||||||||||||||||
| systemic lupus erythematosus | |||||||||||||||||||||||||||||||||||||||||||||
| temporal arteritis |
| Mouse Phenotypes | immune system phenotype |
decreased T cell proliferation |
abnormal thymocyte activation |
abnormal CD4-positive T cell differentiation |
decreased basophil cell number |
decreased eosinophil cell number |
decreased granulocyte number |
decreased CD4-positive, alpha-beta T cell number |
abnormal leukocyte physiology |
impaired eosinophil recruitment |
abnormal lymphocyte physiology |
abnormal immunoglobulin level |
decreased IgA level |
decreased IgE level |
increased IgE level |
decreased IgG1 level |
decreased IgG2a level |
decreased IgG2b level |
decreased IgG3 level |
abnormal NK cell physiology |
impaired natural killer cell mediated cytotoxicity |
abnormal T cell physiology |
abnormal T-helper 1 physiology |
abnormal T-helper 2 physiology |
abnormal CD8-positive, alpha-beta T cell physiology |
decreased cytotoxic T cell cytolysis |
abnormal T cell activation |
abnormal memory T cell physiology |
abnormal immune system morphology |
abnormal immune system physiology |
abnormal dendritic cell physiology |
abnormal Langerhans cell physiology |
abnormal plasmacytoid dendritic cell physiology |
decreased susceptibility to type IV hypersensitivity reaction |
decreased interferon-gamma secretion |
increased interferon-gamma secretion |
decreased interleukin-13 secretion |
decreased interleukin-17 secretion |
decreased interleukin-21 secretion |
decreased interleukin-4 secretion |
decreased susceptibility to autoimmune diabetes |
increased susceptibility to experimental autoimmune encephalomyelitis |
granulomatous inflammation |
abnormal susceptibility to infection |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||||||||||||||
| Il21rtm1Day/Il21rtm1Day | |||||||||||||||||||||||||||||||||||||||||||||
| Il21rtm1Kopf/Il21rtm1Kopf | * | ||||||||||||||||||||||||||||||||||||||||||||
| Il21rtm1Wjl/Il21rtm1Wjl | |||||||||||||||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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